A manuscript on which Shaun collaborated with Garam (Celine) Han and other members of Frank Pugh’s and Ross Hardison’s labs has been published. “Genome-wide organization of Gata1 and Tal1 determined at high resolution” appears in Molecular and Cell Biology. In the paper, Garam has used ChIP-exo to determine the positional organization of Gata1 and Tal1…
Our review on high-resolution protein-DNA binding assays and associated computational analyses has been published. The article is entitled “Protein-DNA binding in high-resolution“, and appears in Critical Reviews in Biochemistry and Molecular Biology.
Naomi Yamada and Lila Rieber have joined the lab. Both are members of the Bioinformatics & Genomics graduate program.
Akshay Kakumanu in our lab has been awarded a 2014 Dissertation Research Award from the Huck Institutes of the Life Sciences: link Congratulations Akshay!
A paper on which Shaun collaborated with Simona Lodato and colleagues in Paola Arlotta’s lab in Harvard University has been published in Nature Neuroscience. “Gene co-regulation by Fezf2 selects neurotransmitter identity and connectivity of corticospinal neurons” finds that Fezf2 is a selector gene that regulates the expression of gene sets that collectively define mouse corticospinal motor…
Our group manuscript, entitled “An integrated model of multiple-condition ChIP-seq data reveals predeterminants of Cdx2 binding”, has been accepted for publication. The manuscript will be presented at the RECOMB 2014 conference, which will be held in Pittsburgh this year from April 2nd – 5th. As part of the conference submission, the manuscript was also reviewed…
A paper on which we collaborated with Elizabeth Paik and her colleagues in Len Zon’s lab at Harvard University has been published in Stem Cell Reports. The paper, entitled “A Cdx4-Sall4 Regulatory Module Controls the Transition from Mesoderm Formation to Embryonic Hematopoiesis“, examined the functions of Cdx4 and Sall4 during the initiation of zebrafish hematopoiesis using ChIP-seq,…
Two papers which Shaun jointly first-authored with Esteban Mazzoni have been published in the same issue of Nature Neuroscience. In “Synergistic binding of transcription factors to cell-specific enhancers programs motor neuron identity“, we describe the mechanism behind the combinatorial action of transcription factors in motor neuron programming. Specifically, we found that Isl1 cooperates with Phox2a…